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Int J Stroke. 2013 Oct;8 Suppl A100:56-61. doi: 10.1111/j.1747-4949.2012.00949.x. Epub 2012 Dec 11.

Excessive work and risk of haemorrhagic stroke: a nationwide case-control study.

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  • 1Department of Neurology, Seoul National University Bundang Hospital, Seongnam-si, Gyunggi-do, Republic of Korea; Department of Neurology, Clinical Research Centre for Stroke, Seoul National University Hospital, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases.

AIM:

The authors investigated whether excessive working conditions would associate with increased risk of haemorrhagic stroke.

METHODS:

A nationwide matched case-control study database, which contains 940 cases of incident haemorrhagic stroke (498 intracerebral haemorrhages and 442 sub-arachnoid haemorrhages) with 1880 gender- and age- (± 5-year) matched controls, was analysed. Work-related information based on the regular job situation, including type of occupation, regular working time, duration of strenuous activity during regular work and shift work, was gathered through face-to-face interviews. Conditional logistic regression analyses were used for the multivariable analyses.

RESULTS:

Compared with white-collar workers, blue-collar workers had a higher risk for haemorrhagic stroke (odds ratio, 1.33 [95% confidence interval, 1.06-1.66]). Longer regular working time was associated with increased risk of haemorrhagic stroke [odds ratio, 1.38 (95% confidence interval, 1.05-1.81) for 8-12 h/day; odds ratio, 1.95 (95% confidence interval, 1.33-2.86) for ≥ 13 h/day; compared with ≤ 4 h/day]. Exposure to ≥ 8 h/week of strenuous activity also associated haemorrhagic stroke risk [odds ratio, 1.61 (95% confidence interval, 1.26-2.05); compared with no strenuous activity]. Shift work was not associated with haemorrhagic stroke (P = 0.98). Positive associations between working condition indices and haemorrhagic stroke risk were consistent regardless of haemorrhagic stroke sub-types and current employment status.

CONCLUSIONS:

Blue-collar occupation, longer regular working time and extended duration of strenuous activity during work may relate to an increased risk of haemorrhagic stroke.

© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.

KEYWORDS:

haemorrhagic stroke; intracerebral haemorrhage; occupation; sub-arachnoid haemorrhage; working condition; working hour

PMID:
23227896
[PubMed - indexed for MEDLINE]
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