Send to:

Choose Destination
See comment in PubMed Commons below
Hepat Res Treat. 2012;2012:947575. doi: 10.1155/2012/947575. Epub 2012 Nov 22.

Antioxidant therapy in nonalcoholic steatohepatitis.

Author information

  • 1Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Alkhoudh, Muscat 123, Oman ; Department of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC, Canada H3A 1A1.


Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk