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Hepat Res Treat. 2012;2012:947575. doi: 10.1155/2012/947575. Epub 2012 Nov 22.

Antioxidant therapy in nonalcoholic steatohepatitis.

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  • 1Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Alkhoudh, Muscat 123, Oman ; Department of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC, Canada H3A 1A1.

Abstract

Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.

PMID:
23227320
[PubMed]
PMCID:
PMC3512254
Free PMC Article
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