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J Sep Sci. 2012 Dec;35(24):3486-91. doi: 10.1002/jssc.201200467.

Determination of phthalate esters in polyvinyl chloride infusion bag by stir bar sorptive extraction combined with GC.

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  • 1School of Pharmacy, Shenyang Pharmaceutical University, PR China.

Abstract

A novel, efficient, and sensitive stir bar sorptive extraction method coupled with GC for the detection of four kinds of phthalate esters in plasticized polyvinyl chloride infusion bag has been developed and validated. Some experimental parameters including stirring speed, stirring time, pH value, salt concentration, desorption mode, desorption solvents, and desorption time were investigated and optimized. Under optimum condition, the validated assay was found to be linear (r > 0.9945) and LODs were between 1.07 and 2.67 ng for the four analytes. The method exhibited excellent precision with RSD varied from 4.5 to 6.1% (n = 5). The recoveries of the four phthalate esters at two different concentrations ranged from 80.5 to 93.4%. The results showed that the validated method could meet the need of determination of targets and was successfully applied to the analysis of phthalate esters in real samples.

© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
23225714
[PubMed - indexed for MEDLINE]
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