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J Perinatol. 2013 Jun;33(6):457-61. doi: 10.1038/jp.2012.145. Epub 2012 Dec 6.

Congenital heart defects in a large, unselected cohort of monochorionic twins.

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  • 1Department of Reproductive Medicine, University of California, San Diego Health System, San Diego, CA 92103-8433, USA. kpettit@stanfordalumni.org

Abstract

OBJECTIVE:

To determine the prevalence of congenital heart defects (CHDs) in a large, unselected cohort of monochorionic (MC) twins.

STUDY DESIGN:

We completed a chart review of all MC twin pregnancies in the Kaiser Permanente Northern California population from 1996 to 2003. CHDs were identified by diagnostic codes and confirmed by postnatal echocardiograms. Follow-up was obtained through one year of age.

RESULT:

A total of 926 liveborn MC twins met inclusion criteria. The prevalence of CHDs was 7.5%, 11.6 times the general population rate (CI 9.2 to 14.5). Septal defects were most common. 20% of infants with heart defects had twin-to-twin transfusion syndrome (TTTS) versus 8% of infants without defects (P<0.01); this association remained significant when controlling for potential confounders.

CONCLUSION:

The prevalence of CHDs in this large cohort of MC twins was significantly higher than the general population rate, with TTTS an added risk factor.

PMID:
23223160
[PubMed - indexed for MEDLINE]
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