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    Biochem Biophys Res Commun. 1990 Mar 30;167(3):904-9.

    Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form.

    Decock B, Conings R, Lenaerts JP, Billiau A, Van Damme J.

    Source

    Rega Institute for Medical Research, University of Leuven, Belgium.

    Abstract

    The chemotactic activity for monocytes in culture supernatants from double-stranded RNA-stimulated human MG-63 osteosarcoma cells and from LPS-stimulated human monocytes was purified to homogeneity and characterized by amino acid sequence analysis. The chemotactic protein derived from the fibroblastoid osteosarcoma cells had a blocked N-terminus but sequencing of tryptic fragments showed that it was identical with a recently identified monocyte chemoattractant designated MCP-1 or MCAF isolated from glioma or myelomonocytic cells, respectively. Preparations of monocyte -derived chemotactic activity appeared to contain not only the blocked protein, but also a novel N-terminally processed form of this molecule, lacking 5 amino acid residues.

    PMID:
    2322286
    [PubMed - indexed for MEDLINE]

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