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Biosci Biotechnol Biochem. 2012;76(12):2310-2. Epub 2012 Dec 7.

Inhibitory effect of ellagitannin metabolites on IgE-mediated allergic responses in RBL-2H3 cells.

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  • 1Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan. naganot@mw.kawasaki-m.ac.jp


The effects of four ellagitannin metabolites (M1-M4) and ellagic acid on immunoglobulin E-mediated allergic responses in rat basophilic leukemia-2H3 cells were investigated. M1-M4 inhibited the antigen-induced degranulation and secretion of interleukin-4 and tumor necrosis factor-α, but ellagic acid only slightly did so under the same experimental conditions. M1 inhibited the activation of the mitogen-activated protein kinases in antigen-stimulated cells.

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