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Am J Med Sci. 2013 Oct;346(4):269-72. doi: 10.1097/MAJ.0b013e3182750375.

Predictor of poor coronary collaterals in elderly population with significant coronary artery disease.

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  • 1Division of Cardiology (P-CH, HMS, H-MS, W-CT, W-CV, W-TL, S-HS, T-HL), Department of Internal Medicine and Department of Medical Research (S-HJ), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Internal Medicine (H-MS, W-CV, W-TL, T-HL), Faculty of Medicine, Graduate Institute of Medicine (P-CH), Medical Genetics (S-HJ), and Center of Excellence for Environmental Medicine (S-HJ, S-HS), Kaohsiung Medical University, Kaohsiung, Taiwan; and Department of Internal Medicine (H-MS), Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.



Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Advanced age might be associated with poor coronary collateral development and cardiovascular outcome. However, limited studies investigate the predictors for collateral development in the elderly population.


The authors evaluated 950 consecutive patients undergoing coronary angiography and finally analyzed 207 patients of 65 years or more. The collateral scoring system developed by Rentrop was used to classify patients into those with poor or good collateral formation.


The patients with poor collateral were older age, had lower incidence of smoking, more male sex, had fewer diseased vessels and had a trend to be diabetic. Multivariate analysis showed age (odds ratio (OR) = 1.068; P = 0.019), diabetes (OR = 2.681; P = 0.003) and diseased vessels numbers (OR = 0.337; P < 0.001) were significant predictors of poor collaterals development. Furthermore, age and diabetes have a synergistic effect on poor collateral development (P = 0.041 for interaction).


Even in the elderly population, age and diabetes might negatively influence the coronary collaterals development.

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