Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats

Noriaki Hidaka; Katsuya Suemaru; Yoshihisa Kato; Hiroaki Araki

doi:10.1016/j.eplepsyres.2012.09.017

Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats

Epilepsy Res. 2013 Mar;104(1-2):181-5. doi: 10.1016/j.eplepsyres.2012.09.017. Epub 2012 Dec 4.

Authors

Noriaki Hidaka¹, Katsuya Suemaru, Yoshihisa Kato, Hiroaki Araki

Affiliation

¹ Division of Pharmacy, Ehime University Hospital, Shitsukawa, Toon, Ehime 791-0295, Japan. noridah@m.ehime-u.ac.jp

PMID: 23219030
DOI: 10.1016/j.eplepsyres.2012.09.017

Abstract

A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated ECS caused a reduction of α4 nAChR-positive cells in the prefrontal cortex and hippocampus. Thus, the α4β2 nAChR is related to ECS-induced deficits in rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electric Stimulation
Electroshock / methods
Isoxazoles / pharmacology
Isoxazoles / therapeutic use
Male
Memory Disorders / drug therapy
Memory Disorders / genetics
Memory Disorders / physiopathology*
Memory, Short-Term* / drug effects
Memory, Short-Term* / physiology
Pyrrolidines / pharmacology
Pyrrolidines / therapeutic use
Rats
Rats, Wistar
Receptors, Nicotinic / genetics
Receptors, Nicotinic / physiology*
Recurrence
Seizures / drug therapy
Seizures / genetics
Seizures / physiopathology*

Substances

Isoxazoles
Pyrrolidines
Receptors, Nicotinic
nicotinic receptor alpha4beta2
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole