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Curr Biol. 2012 Dec 4;22(23):R1006-9. doi: 10.1016/j.cub.2012.10.037.

Nuclear transport: beginning to gel?

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  • 1Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA. mpowers@emory.edu

Abstract

The massive nuclear pore complex mediates nucleocytoplasmic traffic ranging from a single histone to a viral genome. To date, dissecting mechanism has been more an exercise in prediction than biochemical certainty. A recent study combines recombinant proteins with nuclei reconstituted in vitro to test predictions in a startlingly productive manner.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
23218007
[PubMed - indexed for MEDLINE]
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