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Neuron. 2012 Dec 6;76(5):859-61. doi: 10.1016/j.neuron.2012.11.018.

Stealth attack: plaque-specific antibody allows for efficient Aβ removal without side effects.

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  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.


Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.

Copyright © 2012 Elsevier Inc. All rights reserved.

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