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Cell Stem Cell. 2012 Dec 7;11(6):836-44. doi: 10.1016/j.stem.2012.09.012.

MEF promotes stemness in the pathogenesis of gliomas.

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  • 1Cancer Biology and Genetics Program, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy.

Abstract

High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
23217424
[PubMed - indexed for MEDLINE]
PMCID:
PMC3812924
Free PMC Article
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