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Indian J Exp Biol. 2012 Oct;50(10):708-13.

Effect of Pinus massoniana Lamb. bark extract on lytic cycle of Epstein-Barr virus.

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  • 1College of Life Science, Henan Agriculture University, Zhenzhou, Henan, China.

Abstract

Pinus massoniana bark extract (PMBE) at a concentration of 60 microg/mL or more inhibits the expression of Epstein-Barr virus (EBV) lytic proteins, such as Rta, Zta, and EA-D. EBV lytic cycle was blocked by inhibiting the transcription of immediate-early genes. The results suggest that the PMBE has anti-EBV activity. Thus, the extract is potentially useful in preventing the lytic development of EBV in vitro.

PMID:
23214264
[PubMed - indexed for MEDLINE]
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