Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Transl Neurodegener. 2012 Aug 21;1(1):17. doi: 10.1186/2047-9158-1-17.

Reduced striatal volumes in Parkinson's disease: a magnetic resonance imaging study.

Author information

  • 1Department of Medicine, University of Otago, Christchurch, New Zealand. toni.pitcher@otago.ac.nz.

Abstract

BACKGROUND:

The presence and extent of structural changes in the brain as a consequence of Parkinson's disease (PD) is still poorly understood.

METHODS:

High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined. Putamen, caudate, and intracranial volumes were manually traced in the axial plane of 3D reconstructed images. Striatal nuclei volumes were normalized to intracranial volume for statistical comparison. Disease status was assessed using the Unified Parkinson's Disease Rating Scale and Hoehn and Yahr scale. Cognitive status was assessed using global status tests and detailed neuropsychological testing.

RESULTS:

Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender. Caudate volumes were reduced by 11% (p = 0.001) and putamen volumes by 8.1% (p = 0.025). PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.

CONCLUSION:

Small, but significant reductions in the volume of both the caudate and putamen occur in PD brains. These reductions are independent of the effects of age and gender, however the relation of these reductions to the functional loss of dopamine, which is characteristic of PD, remains unclear.

PMID:
23210661
[PubMed]
PMCID:
PMC3514123
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk