A new member of the leucine zipper class of protei...[Science. 1990]

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1: Science. 1990 Mar 30;247(4950):1581-4. Links

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, Glimcher LH.

Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.

Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region. A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun. Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells.

PMID: 2321018 [PubMed - indexed for MEDLINE]

Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.
Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4309-12.

[Proc Natl Acad Sci U S A. 1991]
Regulation of major histocompatibility (MHC) class II human leukocyte antigen-DR alpha gene expression in thyrocytes by single strand binding protein-1, a transcription factor that also regulates thyrotropin receptor and MHC class I gene expression.
Endocrinology. 1998 May; 139(5):2300-13.

[Endocrinology. 1998]
The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.
J Biol Chem. 1993 Aug 15; 268(23):17074-82.

[J Biol Chem. 1993]
ReviewHuman proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
Science. 1987 Dec 4; 238(4832):1386-92.

[Science. 1987]
ReviewTranscriptional regulation of HLA-DRA gene.
Res Immunol. 1991 Jun-Aug; 142(5-6):393-9.

[Res Immunol. 1991]
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Cited by 55 PubMed Central articles

Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo.
Ren Y, Yang S, Xu S, Gao M, Huang W, Gao T, Fang Q, Quan C, Zhang C, Sun L, et al. PLoS Genet. 2009 Jun; 5(6):e1000523. Epub 2009 Jun 19.

[PLoS Genet. 2009]
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, et al. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8326-31. Epub 2009 May 1.

[Proc Natl Acad Sci U S A. 2009]
Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection.
Bowick GC, Spratt HM, Hogg AE, Endsley JJ, Wiktorowicz JE, Kurosky A, Luxon BA, Gorenstein DG, Herzog NK. J Virol. 2009 Jan; 83(2):687-700. Epub 2008 Nov 12.

[J Virol. 2009]
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