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Beilstein J Org Chem. 2012;8:1844-8. doi: 10.3762/bjoc.8.212. Epub 2012 Oct 29.

Rh(III)-catalyzed directed C-H bond amidation of ferrocenes with isocyanates.

Author information

  • 1Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Okubo, Shinjuku, Tokyo, 169-8555, Japan.

Abstract

[RhCp*(OAc)(2)(H(2)O)] [Cp* = pentamethylcyclopentadienyl] catalyzed the C-H bond amidation of ferrocenes possessing directing groups with isocyanates in the presence of 2 equiv/Rh of HBF(4)·OEt(2). A variety of disubstituted ferrocenes were prepared in high yields, or excellent diastereoselectivities.

KEYWORDS:

C–H activation; C–H functionalization; amidation; ferrocene; rhodium

PMID:
23209521
[PubMed]
PMCID:
PMC3511021
Free PMC Article
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