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Nat Rev Microbiol. 2013 Jan;11(1):9-13. doi: 10.1038/nrmicro2917. Epub 2012 Dec 3.

Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB.

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  • Division of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. Dale.Wigley@icr.ac.uk


In bacteria, the processing of double-strand DNA breaks is mediated by the RecBCD, AddAB and AdnAB complexes. These multisubunit helicase-nuclease machines resect the DNA ends and load RecA protein to initiate homologous recombination. Recent studies have revealed fascinating insights into the molecular mechanisms of this process and the evolution of these machines.

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