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Neurology. 1990 Apr;40(4):677-9.

Abnormal respiration and sudden death during sleep in multiple system atrophy with autonomic failure.

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  • 1State University of New York, Buffalo.

Abstract

We studied respiration during sleep in 7 patients with multiple system atrophy and autonomic failure (MSA-AF) and 7 control subjects. Although mean respiratory rate, tidal volume, and inspiratory flow rate were statistically similar in both groups, the coefficients of variability in all were significantly greater in MSA-AF patients. Four of 5 nontracheostomized had evidence of upper airway obstruction without significant oxygen desaturation. Three of these 5 patients died suddenly during sleep. MSA-AF is associated with upper airway dysfunction and disordered central respirations which can be life threatening. Evidence of even mild obstruction during sleep should warrant tracheostomy.

PMID:
2320245
[PubMed - indexed for MEDLINE]
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