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Cancer Lett. 2013 Mar 1;330(1):57-66. doi: 10.1016/j.canlet.2012.11.020. Epub 2012 Nov 28.

Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics.

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  • 1Laboratório de Células Tronco, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil. carolpanis@sercomtel.com.br

Abstract

This study evaluated the plasmatic proteomic profile of breast cancer patients in the early (ED) and advanced (AD) stages, employing high-throughput proteomics. We identified 92 differentially expressed proteins in ED and 73 proteins in AD patients. Gelsolin, lumican, clusterin, SALL4 and PMS2, as well hTERT, TNF-α and GRHL3 were chosen for further investigation. ED presented augmented expression of GRHL3 and reduced circulating TNF-α with high expression of GRHL3 in tumors. AD displayed high TNF-α and a significant expression of PMS2 in tumors. These findings suggest processes enrolling stem cell division in ED, with TNF-α signaling and DNA mismatch repair in the advanced stage.

Copyright © 2012. Published by Elsevier Ireland Ltd.

PMID:
23200674
[PubMed - indexed for MEDLINE]
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