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Chemistry. 2013 Jan 7;19(2):761-70. doi: 10.1002/chem.201202859. Epub 2012 Nov 29.

Diversity-oriented enantioselective synthesis of highly functionalized cyclic and bicyclic alcohols.

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  • 1Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.


The copper-catalyzed hetero-allylic asymmetric alkylation (h-AAA) of functionalized Grignard reagents that contain alkene or alkyne moieties has been achieved with excellent regio- and enantioselectivity. The corresponding alkylation products were further transformed into a variety of highly functionalized cyclic and bicyclic alcohols with excellent control over the chemo-, regio-, and stereoselectivity.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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