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J Vet Intern Med. 2013 Jan-Feb;27(1):62-8. doi: 10.1111/jvim.12018. Epub 2012 Nov 29.

Echocardiographic evidence of left ventricular hypertrophy in obese dogs.

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  • 1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Abstract

BACKGROUND:

Cardiomyopathy of obesity occurs in humans, but the gross and cellular myocardial response to obesity in dogs is not well defined.

OBJECTIVES:

To characterize in vivo myocardial morphology and function in normotensive obese dogs, and quantitate collagen, triglyceride and myocyte cross-sectional area (CSA) in postmortem tissues from obese dogs.

ANIMALS:

Echocardiographic-Doppler measurements of normotensive obese dogs (n = 19) without historical or physical examination evidence of disease, and lean healthy dogs (n = 19) matched for age and ideal weight. Postmortem data were obtained from a separate population of 4 obese and 12 lean dogs without evidence of cardiac disease.

METHODS:

A prospective, observational study of myocardial morphology and function was conducted by echocardiographic-Doppler measurement. Left ventricular (LV) tissue was collected for quantitation of triglyceride, collagen, and myocyte CSA.

RESULTS:

Compared with lean control dogs, obese dogs had increased systolic blood pressure (obese 153 ± 19 mm Hg; lean 133 ± 20 mm Hg; P = .003), and increased LV free wall thickness at end-diastole (obese 9.9 ± 1.8 mm, lean 8.7 ± 1.5 mm; P = .03) and end-systole (obese 15.2 ± 2.3 mm, lean 12.9 ± 2.3 mm; P = .004). Isovolumic relaxation time was prolonged in 7/19 (37%) of obese dogs, compared with normal ranges. Myocardial triglyceride and collagen content and myocyte CSA were similar between groups.

CONCLUSIONS AND CLINICAL IMPORTANCE:

As in humans, LV hypertrophy and diastolic dysfunction can be an early myocardial change in some obese dogs.

Copyright © 2012 by the American College of Veterinary Internal Medicine.

PMID:
23194177
[PubMed - indexed for MEDLINE]
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