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Chem Soc Rev. 2013 Feb 7;42(3):1121-46. doi: 10.1039/c2cs35397k.

Recent approaches for C-C bond formation via direct dehydrative coupling strategies.

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  • 1Laboratory for Organic & Microwave-Assisted Chemistry, (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium.

Abstract

In recent years, reaction of inexpensive and abundantly available alcohols (C-OH) with unactivated nucleophilic coupling partners (C-H), leading to the construction of the C-C bond, has emerged as one of the vital strategies since it is an atom-economical and environmentally benign approach with water as the by-product. Various transition metal-catalyzed or metal-free approaches for the direct dehydrative coupling employing the C-OH bond (including in situ activation) have recently been devised. This review article aims to highlight advances in such waste-free C-C bond forming dehydrative strategies.

PMID:
23192192
[PubMed - indexed for MEDLINE]
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