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Pediatr Infect Dis J. 2013 May;32(5):486-8. doi: 10.1097/INF.0b013e31827b4775.

Performance of the first fourth-generation rapid human immunodeficiency virus test in children.

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  • 1Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, Parktown, South Africa. kbhowan@gmail.com


Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger.

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