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J Clin Pharm Ther. 1990 Feb;15(1):41-4.

Stability of solutions of histamine acid phosphate after sterilization by heating in an autoclave.

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  • 1School of Pharmacy, Curtin University of Technology, Perth, Western Australia.


Histamine acid phosphate (HAP) solutions are used in tests for asthma and also as positive controls in general allergenic testing. Previously these solutions have been sterilized, if at all, by filtration, thus limiting the shelf-life of the preparation and introducing some degree of uncertainty in their use. It is shown here that HAP solutions can be sterilized successfully by heating in an autoclave with little degradation and that subsequent storage of autoclaved solutions indicates a minimum shelf-life of 4 months.

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