Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2012 Dec 3;122(12):4341-3. doi: 10.1172/JCI66171. Epub 2012 Nov 26.

Are epsins a therapeutic target for tumor angiogenesis?

Author information

  • Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. nancy_demore@med.unc.edu


Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins--proteins involved in endocytosis--in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.

Comment on

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Write to the Help Desk