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J Clin Invest. 2012 Dec 3;122(12):4341-3. doi: 10.1172/JCI66171. Epub 2012 Nov 26.

Are epsins a therapeutic target for tumor angiogenesis?

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  • Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. nancy_demore@med.unc.edu

Abstract

Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins--proteins involved in endocytosis--in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.

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PMID:
23187137
[PubMed - indexed for MEDLINE]
PMCID:
PMC3533565
Free PMC Article

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