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Bioorg Med Chem Lett. 2013 Jan 1;23(1):244-7. doi: 10.1016/j.bmcl.2012.10.109. Epub 2012 Nov 2.

Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

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  • 1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.


Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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