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Nucleic Acids Res. 2013 Jan;41(Database issue):D408-14. doi: 10.1093/nar/gks1177. Epub 2012 Nov 26.

DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters.

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  • 1Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-49-10 Nishihara, Shibuya-ku, Tokyo 151-0006, Japan.


This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated,, a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.

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