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Adv Healthc Mater. 2012 May;1(3):321-5. doi: 10.1002/adhm.201100030. Epub 2012 Mar 27.

Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity.

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  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR of China.


A nanoreservoir for efficient intracellular anticancer drug delivery based on mesoporous silica nanoparticles end-capped with lactobionic acid-grafted bovine serum albumin is fabricated. It demonstrates great potential for both cell-specific endocytosis and intracellular pH-responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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