Format

Send to:

Choose Destination
See comment in PubMed Commons below
Radiol Med. 2013 Aug;118(5):882-94. doi: 10.1007/s11547-012-0900-0. Epub 2012 Nov 26.

[Curative radiotherapy in patients with anal cancer: clinical outcomes and prognostic factors in a single-institution experience].

[Article in Italian]

Author information

  • 1Department of Radiation Oncology, Sant'Andrea Hospital, La Sapienza University, Rome, Italy.

Abstract

PURPOSE:

Our aim was to retrospectively analyse a series of patients with anal cancer treated with curative intent at a single institute in terms of survival and local disease control.

MATERIALS AND METHODS:

Forty-two patients with anal cancer were treated with primary radiotherapy with or without concurrent chemotherapy. The influence of the prognostic factors on overall (OS), disease-free (DFS), disease-specific (DSS), colostomy-free (CFS) and metastasis-free (MFS) survival was evaluated.

RESULTS:

Nine patients had stage I, 15 stage II, four stage IIIA and 14 stage IIIB disease. Tumour progression/ persistence occurred in five patients (12%). The 5-year OS, DSS, DFS, CFS and MFS were 72.7%, 84.2%, 85.7%, 81.1% and 87.1%, respectively. On univariate analysis, T stage emerged as highly significant for OS, DSS, CFS and DFS, whereas N status was a significant prognostic factor for DSS. On multivariate analysis, T stage was a significant prognostic factor for OS and CFS.

CONCLUSIONS:

Our data support the view that combined chemoradiation treatment of anal cancer is feasible and may provide survival benefits with an acceptable rate of adverse effects. We should consider T and N stages as important prognostic factors for survival.

PMID:
23184242
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk