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J Trace Elem Med Biol. 2013 Apr;27(2):154-9. doi: 10.1016/j.jtemb.2012.09.003. Epub 2012 Nov 22.

The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs.

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  • 1Department of Chemistry, University of Incheon, Incheon, Republic of Korea.

Abstract

We investigated the preventive effect of Se-methylselenocysteine (MSC) administration on γ-radiation (whole body irradiation, single 10-Gy dose)-induced oxidative damage in rat lungs. Rats were pretreated with MSC (0.75mg/rat/day) for 1 week before γ-irradiation. The MSC pretreatment prevented the irradiation-induced increase in lipid peroxidation and the concomitant decrease in cellular glutathione content. The prevention of irradiation-induced oxidative damage in MSC-pretreated rat lungs appeared to be associated with increased antioxidant capacity, particularly in the glutathione system. The 1-week MSC treatment resulted in an increase in glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase activities, which are involved in glutathione redox cycling. An increase in catalase activity was also observed in the rat lungs. Additionally, a significantly increased level of nuclear factor erythroid 2-related factor 2 (Nrf2) was exhibited in the MSC-treated rat lungs. Heme oxygenase 1, glutathione S-transferase pi, and peroxiredoxin 1, which are known target proteins of Nrf2, were also increased in MSC-treated lungs. These results implicate Nrf2 signaling in the MSC-induced activation of the antioxidant system.

Copyright © 2012 Elsevier GmbH. All rights reserved.

PMID:
23176811
[PubMed - indexed for MEDLINE]
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