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Gerodontology. 2014 Jun;31(2):111-6. doi: 10.1111/ger.12015. Epub 2012 Nov 26.

Association between low renal function and tooth loss over 5 years.

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  • 1Department of Oral Health and Welfare, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.



This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.


Subjects comprised 406 female subjects (55-74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years.


Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (p=0.029).


This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

© 2012 The Gerodontology Society and John Wiley & Sons A/S.


epidemiology; longitudinal study; renal function; tooth loss

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