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Gerodontology. 2014 Jun;31(2):111-6. doi: 10.1111/ger.12015. Epub 2012 Nov 26.

Association between low renal function and tooth loss over 5 years.

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  • 1Department of Oral Health and Welfare, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Abstract

OBJECTIVES:

This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.

MATERIAL AND METHODS:

Subjects comprised 406 female subjects (55-74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years.

RESULTS:

Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (p=0.029).

CONCLUSION:

This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

© 2012 The Gerodontology Society and John Wiley & Sons A/S.

KEYWORDS:

epidemiology; longitudinal study; renal function; tooth loss

PMID:
23176113
[PubMed - in process]
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