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Acta Chir Belg. 2012 Sep-Oct;112(5):365-8.

Neutrophil-lymphocyte ratio predicts graft patency following lower limb revascularisation.

Author information

  • 1Vascular Surgery Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, U.K. peterkullar@doctors.org.uk

Abstract

BACKGROUND:

Graft failure is a significant problem following lower limb revascularisation. We hypothesised that the neutrophil-lymphocyte ratio (NLR), a simple and inexpensive index of systemic inflammation, predicts graft failure.

METHODS:

Consecutive patients undergoing infra-inguinal bypass grafting were identified from a prospective database. All patients underwent routine graft surveillance using Duplex ultrasound. Potential predictors of graft failure (occlusion or ipsilateral amputation) were assessed in univariate and multivariate regression models.

RESULTS:

Of 126 patients, 79 had patent grafts at 1 year. The only independent predictor of graft failure was the postoperative NLR.

CONCLUSION:

Post-operative NLR may be a simple, inexpensive means of focussing surveillance resources on patients at high-risk of graft failure. Its value needs to be confirmed in larger cohorts.

PMID:
23175925
[PubMed - indexed for MEDLINE]
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