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Nig Q J Hosp Med. 2011 Oct-Dec;21(4):299-302.

Effects of ethanolic extract of Tetrapleura tetraptera fruit on serum lipid profile and kidney function in male Dutch-white rabbits.

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  • 1Department of Biochemistry, College of Medicine, University of Lagos, Nigeria. loladot2001@yahoo.com

Abstract

BACKGROUND:

Tetrapleura tetraptera fruit is widely used in Nigeria as a spice and for treatment of various medical ailments. Reports indicate that feeding of extracts to animals produced some toxic effects and pathological lesions in some organs.

OBJECTIVE:

This study was designed to investigate the effects of 10 days oral administration of the ethanolic extract of Tetrapleura tetraptera (TTE) on the lipid profile and kidney function in male rabbits.

METHODS:

Twenty healthy, acclimatized male rabbits weighing 1.4 - 1.6 kg were randomly divided into four groups. Group 1 served as control and received only water while groups 2, 3 and 4 were administered 50, 100 and 150 mg/kg bodyweight of TTE respectively. Fasting serum from all groups were analyzed for lipid profile and kidney function parameters using standard protocols. Data were analyzed using student's t-test and ANOVA.

RESULTS:

Tetrapleura tetraptera extract elicited reduction in serum triacylglycerols, elevation of LDL-cholesterol and alteration of kidney function parameters in male rabbits.

CONCLUSION:

Ethanolic extract of Tetrapleura tetraptera may predispose to hypertension and cardiovascular diseases.

PMID:
23175895
[PubMed - indexed for MEDLINE]
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