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Arch Dis Child. 2013 Jan;98(1):72-6. doi: 10.1136/archdischild-2012-302760. Epub 2012 Nov 22.

Protracted bacterial bronchitis: reinventing an old disease.

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  • 1Department of Respiratory Medicine, Sheffield Children's Hospital, UK.

Abstract

Chronic cough is common in the paediatric population, yet the true prevalence of this condition remains difficult to define. Protracted bacterial bronchitis (PBB) is a disease caused by the chronic infection of the conducting airways. In many children the condition appears to be secondary to impaired mucociliary clearance that creates a niche for bacteria to become established, probably in the form of biofilms. In others, immunodeficiencies, which may be subtle, appear to be a factor. PBB causes persistent coughing and disturbed sleep, and affects exercise tolerance, causing significant levels of morbidity. PBB has remained largely unrecognised and is often misdiagnosed as asthma.

PMID:
23175647
[PubMed - indexed for MEDLINE]
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