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Med Sante Trop. 2012 Jul-Sep;22(3):275-8. doi: 10.1684/mst.2012.0085.

[Amyloidosis in sub-Saharan Africa].

[Article in French]

Author information

  • 1Clinique Médicale 1, CHU Aristide-Le-Dantec, Université Cheikh-Anta-Diop, Dakar, Sénégal.

Abstract

Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited extracellularly as insoluble fibrils. When stained with Congo red dye, it produces apple-green birefringence under polarized light. The main amyloid proteins are AL, AA, ATTR and Aβ(2)-M. The incidence of amyloidosis in sub-Saharan Africa ranges from 0.28 to 0.57% in autopsy series. Secondary AA amyloidosis is the most frequent, found in 42 to 66% of amyloidoses. Chronic infections, especially tuberculosis, are the main cause. AL amyloidosis is found in 21 to 34% of amyloidosis cases, half of them due to myeloma. Other types of amyloidosis seem rare, but are probably underdiagnosed. The clinical presentation in sub-Saharan Africa is similar to that in Western series. Further experimental and clinical studies will allow a better assessment of the characteristics of amyloidosis in sub-Saharan Africa.

PMID:
23174270
[PubMed - indexed for MEDLINE]
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