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Public Health Nutr. 2013 Apr;16(4):687-92. doi: 10.1017/S1368980012003084. Epub 2012 Jul 16.

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size.

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  • 1Department of Pathology and Experimental Medicine, 306 Hospital of PLA, Chao Yang District, Beijing 100101, PR China.

Abstract

OBJECTIVE:

To evaluate the prevalence of vitamin D deficiency in pregnant women and their newborns in Beijing, China and the influence of vitamin D deficiency on birth size.

DESIGN:

A cross-sectional study.

SETTING:

Data were collected from pregnant women who delivered during April to May 2010 at 306 Hospital of PLA in Beijing, China.

SUBJECTS:

Participants in the study were seventy healthy nulliparous pregnant women with singleton pregnancies who delivered healthy babies at full term and their newborns.

RESULTS:

Severe vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25 nmol/l) was detected in 54·5 % of mothers and 46·6 % of newborns. Neither mothers nor newborns had serum 25(OH)D concentrations that reached the normal level (>75 nmol/l). The concentration of 25(OH)D in mothers was positively correlated with that in cord blood (r = 0·89, P < 0·001). Newborns of mothers with severe vitamin D deficiency had lower birth length and birth weight. The head circumference and birth weight were lower in vitamin D-deficient newborns.

CONCLUSIONS:

The study indicates that pregnant women and neonates residing in Beijing are at high risk of vitamin D deficiency. Neonatal 25(OH)D concentrations are dependently related to maternal 25(OH)D levels. Maternal and neonatal vitamin D status influences newborn size.

PMID:
23174124
[PubMed - indexed for MEDLINE]
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