Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Gut Liver. 2012 Oct;6(4):476-81. doi: 10.5009/gnl.2012.6.4.476. Epub 2012 Oct 18.

Changes in the clinical outcomes of variceal bleeding in cirrhotic patients: a 10-year experience in gangwon province, South Korea.

Author information

  • 1Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung, Korea.

Abstract

BACKGROUND/AIMS:

Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding.

METHODS:

We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007).

RESULTS:

A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5%), and variceal ruptures were found in 607 patients (35.6%). The variceal bleeding rate did not decrease in each period (26.0% vs 43.7% vs 33.9%, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5% vs 10.8% vs 6.4%, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4% vs 2.0%, p<0.001; odds ratio, 5.659; 95% confidence interval, 3.445 to 9.295).

CONCLUSIONS:

Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.

KEYWORDS:

Esophageal and gastric varices; Gastrointestinal hemorrhage; Liver cirrhosis; Mortality

PMID:
23170153
[PubMed]
PMCID:
PMC3493729
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Inforang Icon for PubMed Central
    Loading ...
    Write to the Help Desk