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Chem Commun (Camb). 2013 Jan 7;49(2):164-6. doi: 10.1039/c2cc36416f. Epub 2012 Nov 20.

Rational design of Hg2+ controlled streptavidin-binding aptamer.

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  • 1Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Abstract

Through substituting two canonical base pairs of a streptavidin-binding aptamer with T-T mismatched base pairs, a new aptamer was constructed. Its binding ability could be controlled by Hg(2+) through the formation of T-Hg-T metal-base pairs.

PMID:
23168536
[PubMed - indexed for MEDLINE]
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