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Trends Cell Biol. 2013 Feb;23(2):90-101. doi: 10.1016/j.tcb.2012.10.007. Epub 2012 Nov 17.

Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.

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  • 1Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells. Dynamin controls various steps of the intoxication process used by numerous pathogenic bacteria, viruses, and toxins. Targeting dynamin with pharmaceutical compounds may therefore have prophylactic potential. Here we review the growing number of pathogens requiring dynamin-dependent trafficking to intoxicate cells, outline the mode of internalization that leads to their pathogenicity, and highlight the protective effect of pharmacological and genetic approaches targeting dynamin function. We also assess the methodologies used to investigate the role of dynamin in the intoxication process and discuss the validity and potential pitfalls of using dynamin inhibitors (DIs) as therapeutics.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
23164733
[PubMed - indexed for MEDLINE]
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