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Immunity. 2012 Nov 16;37(5):763-6. doi: 10.1016/j.immuni.2012.10.009.

Retroviral danger from within: TLR7 is in control.

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  • 1Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.


In this issue of Immunity, Yu et al. (2012) outline a fascinating model in which TLR7-mediated antibody production acts as a dominant immunosurveillance mechanism against endogenous retroviruses (ERVs), with additional support of TLR3 and TLR9 that function to prevent ERV-mediated malignancy.

Copyright © 2012 Elsevier Inc. All rights reserved.

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