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Genes Dev. 2012 Nov 15;26(22):2468-70. doi: 10.1101/gad.207126.112.

Zebrafish genetics gets the Scube on Hedgehog secretion.

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  • Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore.

Abstract

Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

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PMID:
23154980
[PubMed]
PMCID:
PMC3505816
Free PMC Article

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