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Ann Plast Surg. 2012 Dec;69(6):668-71. doi: 10.1097/SAP.0b013e3182742c45.

MicroRNA signatures in ischemia-reperfusion injury.

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  • 1Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. kapich@kmu.edu.tw

Abstract

BACKGROUND:

MicroRNAs (miRs) are involved in gene expression and function, but little is known of their function in ischemia-reperfusion injury (IRI), which plays a critical role in flap compromise during microvascular flap surgeries. This article aimed to determine the expression profiles of miRs in rat flap surgeries after IRI.

METHODS:

Vessel specimens in rat epigastric flap were initially determined for miRs survey after 2 hours of ischemia and 2 hours of reperfusion. Their miR expressions were further quantified after 2 hours of ischemia and subsequent reperfusion for 2 and 24 hours.

RESULTS:

Only 3 miRs (miR-21, miR-193-3p, and miR-210) in rat vessels, but not in flap tissues, were significantly up-regulated at 24 hours of reperfusion after 2 hours of ischemia.

CONCLUSIONS:

Our findings provide insights into deregulated expressions of miRs in flap surgeries after IRI. They might provide a further therapeutic consideration to prevent vascular compromise due to IRI in flap surgeries.

PMID:
23154340
[PubMed - indexed for MEDLINE]
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