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J Clin Invest. 2012 Nov;122(11):3835-6. doi: 10.1172/JCI66510. Epub 2012 Nov 1.

Autoantibodies, autoimmune disease, and the birth of immune diagnostics.

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  • 1The Scripps Research Institute, La Jolla, California 92037, USA. emtan@scripps.edu

Abstract

The appearance of autoantibody to DNA followed sequentially by the disappearance of anti-DNA and appearance of DNA antigen in a patient with systemic lupus erythematosus demonstrated that autoantibodies participate in immune complex-mediated pathogenesis. Continuing studies showed that autoantibodies are also useful biomarkers in clinical diagnosis and important reagents for elucidating the structure and function of intracellular proteins in cell biology. Recently, autoantibodies to tumor-associated antigens have been identified in cancer, and these findings have expanded the field of cancer immunodiagnostics.

PMID:
23154275
[PubMed - indexed for MEDLINE]
PMCID:
PMC3484082
Free PMC Article
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