Abstract
Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition sensors for microbial and even self-molecules, have provided new insights into the pathogenesis of both systemic and organ-specific autoimmune diseases. These insights will permit the development of novel treatment modalities for these disorders.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Animals, Congenic
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Antibodies, Antinuclear / immunology
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Antigen Presentation
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Antigen-Presenting Cells / immunology
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Autoantibodies / immunology
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Autoantigens / immunology
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Autoimmunity / immunology*
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Disease Models, Animal
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Endosomes / immunology
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Female
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Humans
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Interferons / immunology*
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Isoantigens / immunology
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Lupus Erythematosus, Systemic / drug therapy
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Lupus Erythematosus, Systemic / etiology
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Lupus Erythematosus, Systemic / immunology
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Male
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Mice
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Mice, Knockout
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Nucleic Acids / immunology
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Toll-Like Receptors / immunology*
Substances
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Antibodies, Antinuclear
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Autoantibodies
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Autoantigens
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Isoantigens
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Nucleic Acids
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Toll-Like Receptors
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Interferons