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Org Lett. 2012 Dec 7;14(23):5816-9. doi: 10.1021/ol3027335. Epub 2012 Nov 15.

Two-stage amplification of receptors using a multilevel orthogonal/simultaneous dynamic combinatorial library.

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  • 1Farmacognosia, Facultad de Ciencias BioquĂ­micas y FarmacĂ©uticas, Universidad Nacional de Rosario, Rosario, Argentina.


Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.

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