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J Contemp Dent Pract. 2012 Jul 1;13(4):425-30.

Grape seed extract as a potential remineralizing agent: a comparative in vitro study.

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  • 1Department of Conservative Dentistry and Endodontics, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India.

Abstract

OBJECTIVE:

Remineralization is an effective treatment that may stop or reverse early tooth decay. Grape seed extract (GSE) is the potential remineralizing agent under investigation.

MATERIALS AND METHODS:

Sound human tooth sections were obtained from the cervical portion of the root and stored in demineralizing solution at 37°C for 96 hours to induce artificial root caries lesions. The sections were divided into four treatment groups including 6.5% grape seed extract, sodium monofluorophosphate (220 ppm) with 0.05% calcium glycerophosphate, 0.5% calcium glycerophosphate and control (no treatment). An in vitro pH cycling model was used to cycle the demineralized specimens through treatment solutions, acidic buffer and neutral buffer for 8 days at 6 cycles per day. Subsequently, they were evaluated using confocal laser scanning microscope. Data were analyzed using analysis of variance (p < 0.05).

RESULTS:

GSE revealed less demineralization and more remineralization compared with other groups.

CONCLUSION:

GSE promotes remineralization of artificial root caries lesions.

CLINICAL SIGNIFICANCE:

The search for the perfect remineralizing agent continues to this day. GSE could be a welcome addition to the remineralization armamentarium.

PMID:
23151686
[PubMed - indexed for MEDLINE]
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