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J Bras Pneumol. 2012 Sep-Oct;38(5):666-71.

Hemophagocytic syndrome due to pulmonary sarcoidosis.

[Article in English, Portuguese]

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  • 1Pedro Ernesto University Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil.


Although hemophagocytic syndrome is a rare clinical condition, it is associated with high mortality and the number of cases described in the literature has progressively increased. The diagnosis of hemophagocytic syndrome is made on the basis of a finding of hemophagocytosis. Sarcoidosis is a highly prevalent disease whose course and prognosis might correlate with the initial clinical presentation and the extent of the disease. We report the case of a patient with long-standing sarcoidosis who presented with intermittent fever and fatigue. The diagnosis of hemophagocytic syndrome was made by bone marrow aspiration, and specific treatment was ineffective. This is the third case of sarcoidosis-related hemophagocytic syndrome reported in the literature and the first reported in Latin America. All three cases had unfavorable outcomes.

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