Nature. 1990 Mar 22;344(6264):309-13.

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

Enver T, Raich N, Ebens AJ, Papayannopoulou T, Costantini F, Stamatoyannopoulos G.

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Department of Medicine, University of Washington, Seattle 98195.

Abstract

Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.

PMID:: 2314472; [PubMed - indexed for MEDLINE]

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