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J Clin Immunol. 2013 Apr;33(3):513-9. doi: 10.1007/s10875-012-9831-8. Epub 2012 Nov 10.

Major histocompatibility complex class II deficiency in Kuwait: clinical manifestations, immunological findings and molecular profile.

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  • 1Department of Pediatrics, Faculty of Medicine, Kuwait University, 24923 Safat, 13110, Kuwait, Kuwait. wemh@hotmail.com


Major Histocompatibility Complex (MHC) class II deficiency is a combined primary immunodeficiency disease that leads to overwhelming and recurrent infections. It was found to account for 19 % of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular features of 11 Kuwaiti patients who presented with MHC class II deficiency between 2004 and 2011.

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