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Clin Neurophysiol. 2013 May;124(5):857-69. doi: 10.1016/j.clinph.2012.09.031. Epub 2012 Nov 8.

Clinical significance and developmental changes of auditory-language-related gamma activity.

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  • 1Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.

Abstract

OBJECTIVE:

We determined the clinical impact and developmental changes of auditory-language-related augmentation of gamma activity at 50-120 Hz recorded on electrocorticography (ECoG).

METHODS:

We analyzed data from 77 epileptic patients ranging 4-56 years in age. We determined the effects of seizure-onset zone, electrode location, and patient-age upon gamma-augmentation elicited by an auditory-naming task.

RESULTS:

Gamma-augmentation was less frequently elicited within seizure-onset sites compared to other sites. Regardless of age, gamma-augmentation most often involved the 80-100 Hz frequency band. Gamma-augmentation initially involved bilateral superior-temporal regions, followed by left-side dominant involvement in the middle-temporal, medial-temporal, inferior-frontal, dorsolateral-premotor, and medial-frontal regions and concluded with bilateral inferior-Rolandic involvement. Compared to younger patients, those older than 10 years had a larger proportion of left dorsolateral-premotor and right inferior-frontal sites showing gamma-augmentation. The incidence of a post-operative language deficit requiring speech therapy was predicted by the number of resected sites with gamma-augmentation in the superior-temporal, inferior-frontal, dorsolateral-premotor, and inferior-Rolandic regions of the left hemisphere assumed to contain essential language function (r(2) = 0.59; p = 0.001; odds ratio = 6.04 [95% confidence-interval: 2.26-16.15]).

CONCLUSIONS:

Auditory-language-related gamma-augmentation can provide additional information useful to localize the primary language areas.

SIGNIFICANCE:

These results derived from a large sample of patients support the utility of auditory-language-related gamma-augmentation in presurgical evaluation.

Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PMID:
23141882
[PubMed - indexed for MEDLINE]
PMCID:
PMC3577943
Free PMC Article
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