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Case Rep Dermatol. 2012 Sep;4(3):211-4. doi: 10.1159/000343882. Epub 2012 Oct 12.

Bullous Pemphigoid Accompanied by Aplastic Anemia: The Induction of IL-17-Producing Cells in the Affected Areas of the Skin.

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  • 1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Abstract

Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.

KEYWORDS:

Aplastic anemia; Bullous pemphigoid; IL-17

PMID:
23139659
[PubMed]
PMCID:
PMC3493012
Free PMC Article
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